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Resminostat hydrochloride
CAS No. 1187075-34-8
Resminostat hydrochloride ( RAS2410 hydrochloride;4SC-201 hydrochloride )
Catalog No. M10639 CAS No. 1187075-34-8
A potent inhibitor of HDAC1/3/6 with IC50s of 43-72 nM; induces hyperacetylation of histone H4 and apoptosis in MM cell lines (IC50=2.5-3 uM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 77 | Get Quote |
|
| 10MG | 149 | Get Quote |
|
| 25MG | 293 | Get Quote |
|
| 50MG | 520 | Get Quote |
|
| 100MG | 750 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameResminostat hydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionA potent inhibitor of HDAC1/3/6 with IC50s of 43-72 nM; induces hyperacetylation of histone H4 and apoptosis in MM cell lines (IC50=2.5-3 uM).
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DescriptionA potent inhibitor of HDAC1/3/6 with IC50s of 43-72 nM; induces hyperacetylation of histone H4 and apoptosis in MM cell lines (IC50=2.5-3 uM); decreases levels of cyclin D1, cdc25a, Cdk4 and pRb as well as upregulation of p21; downregulates phosphorylation of 4E-BP1 and p70S6k.Liver Cancer Phase 2 Clinical
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SynonymsRAS2410 hydrochloride;4SC-201 hydrochloride
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PathwayCell Cycle/DNA Damage
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TargetHDAC
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RecptorHDAC1;HDAC3;HDAC6;HDAC8
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Research AreaCancer
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IndicationLiver Cancer
Chemical Information
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CAS Number1187075-34-8
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Formula Weight385.87
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Molecular FormulaC16H20ClN3O4S
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Purity>98% (HPLC)
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SolubilityDMSO: ≥ 50 mg/mL
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SMILESO=C(NO)/C=C/C1=CN(S(=O)(C2=CC=C(CN(C)C)C=C2)=O)C=C1.[H]Cl
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Chemical Name2-Propenamide, 3-[1-[[4-[(dimethylamino)methyl]phenyl]sulfonyl]-1H-pyrrol-3-yl]-N-hydroxy-, hydrochloride (1:1), (2E)-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Mandl-Weber S, et al. Br J Haematol. 2010 May;149(4):518-28.
2. Fu M, et al. Biochem Biophys Res Commun. 2016 Sep 2;477(4):527-33.
3. Enzenhofer E, et al. Head Neck. 2017 May;39(5):900-907.
2. Fu M, et al. Biochem Biophys Res Commun. 2016 Sep 2;477(4):527-33.
3. Enzenhofer E, et al. Head Neck. 2017 May;39(5):900-907.
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