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Home - Products - Cell Cycle/DNA Damage - HDAC - Resminostat hydrochloride

Resminostat hydrochloride

CAS No. 1187075-34-8

Resminostat hydrochloride ( RAS2410 hydrochloride;4SC-201 hydrochloride )

Catalog No. M10639 CAS No. 1187075-34-8

A potent inhibitor of HDAC1/3/6 with IC50s of 43-72 nM; induces hyperacetylation of histone H4 and apoptosis in MM cell lines (IC50=2.5-3 uM).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Resminostat hydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent inhibitor of HDAC1/3/6 with IC50s of 43-72 nM; induces hyperacetylation of histone H4 and apoptosis in MM cell lines (IC50=2.5-3 uM).
  • Description
    A potent inhibitor of HDAC1/3/6 with IC50s of 43-72 nM; induces hyperacetylation of histone H4 and apoptosis in MM cell lines (IC50=2.5-3 uM); decreases levels of cyclin D1, cdc25a, Cdk4 and pRb as well as upregulation of p21; downregulates phosphorylation of 4E-BP1 and p70S6k.Liver Cancer Phase 2 Clinical
  • Synonyms
    RAS2410 hydrochloride;4SC-201 hydrochloride
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    HDAC
  • Recptor
    HDAC1;HDAC3;HDAC6;HDAC8
  • Research Area
    Cancer
  • Indication
    Liver Cancer

Chemical Information

  • CAS Number
    1187075-34-8
  • Formula Weight
    385.87
  • Molecular Formula
    C16H20ClN3O4S
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: ≥ 50 mg/mL
  • SMILES
    O=C(NO)/C=C/C1=CN(S(=O)(C2=CC=C(CN(C)C)C=C2)=O)C=C1.[H]Cl
  • Chemical Name
    2-Propenamide, 3-[1-[[4-[(dimethylamino)methyl]phenyl]sulfonyl]-1H-pyrrol-3-yl]-N-hydroxy-, hydrochloride (1:1), (2E)-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Mandl-Weber S, et al. Br J Haematol. 2010 May;149(4):518-28.
2. Fu M, et al. Biochem Biophys Res Commun. 2016 Sep 2;477(4):527-33.
3. Enzenhofer E, et al. Head Neck. 2017 May;39(5):900-907.
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